Ontology highlight
ABSTRACT:
SUBMITTER: Forsman H
PROVIDER: S-EPMC3370598 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Forsman Huamei H Christenson Karin K Bylund Johan J Dahlgren Claes C
Infection and immunity 20120319 6
The virulence and pathogenesis mechanisms of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains depend on a newly described group of phenol-soluble modulin (PSM) peptides (the PSMα peptides) with cytolytic activity. These toxins are α-helical peptides with a formyl group at the N terminus, and they activate neutrophils through formyl peptide receptor 2 (FPR2), a function closely correlated to the capacity of staphylococcal species to cause invasive infections. The ...[more]