The composition of the culture medium influences the ?-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of ?-1,3-glucan synthesis.
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ABSTRACT:
SUBMITTER: Clavaud C
PROVIDER: S-EPMC3370737 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
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The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis.
Clavaud Cécile C Beauvais Anne A Barbin Lise L Munier-Lehmann Hélène H Latgé Jean-Paul JP
Antimicrobial agents and chemotherapy 20120305 6
In vitro testing of Aspergillus fumigatus susceptibility to echinocandins has always been a challenge. Using a simple and quick colorimetric method to analyze the activity of inhibitors of β-1,3-glucan synthesis, we found that the composition of the culture medium significantly influences glucan synthesis and consequently the antifungal properties of inhibitors of β-1,3-glucan synthesis when they are tested alone or in combination with chitin synthase inhibitors. ...[more]
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