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The composition of the culture medium influences the ?-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of ?-1,3-glucan synthesis.


ABSTRACT: In vitro testing of Aspergillus fumigatus susceptibility to echinocandins has always been a challenge. Using a simple and quick colorimetric method to analyze the activity of inhibitors of ?-1,3-glucan synthesis, we found that the composition of the culture medium significantly influences glucan synthesis and consequently the antifungal properties of inhibitors of ?-1,3-glucan synthesis when they are tested alone or in combination with chitin synthase inhibitors.

SUBMITTER: Clavaud C 

PROVIDER: S-EPMC3370737 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis.

Clavaud Cécile C   Beauvais Anne A   Barbin Lise L   Munier-Lehmann Hélène H   Latgé Jean-Paul JP  

Antimicrobial agents and chemotherapy 20120305 6


In vitro testing of Aspergillus fumigatus susceptibility to echinocandins has always been a challenge. Using a simple and quick colorimetric method to analyze the activity of inhibitors of β-1,3-glucan synthesis, we found that the composition of the culture medium significantly influences glucan synthesis and consequently the antifungal properties of inhibitors of β-1,3-glucan synthesis when they are tested alone or in combination with chitin synthase inhibitors. ...[more]

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