Ontology highlight
ABSTRACT:
SUBMITTER: Skinner-Adams TS
PROVIDER: S-EPMC3370795 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Skinner-Adams Tina S TS Peatey Christopher L CL Anderson Karen K Trenholme Katharine R KR Krige David D Brown Christopher L CL Stack Colin C Nsangou Desire M M DM Mathews Rency T RT Thivierge Karine K Dalton John P JP Gardiner Donald L DL
Antimicrobial agents and chemotherapy 20120326 6
Malaria remains a significant risk in many areas of the world, with resistance to the current antimalarial pharmacopeia an ever-increasing problem. The M1 alanine aminopeptidase (PfM1AAP) and M17 leucine aminopeptidase (PfM17LAP) are believed to play a role in the terminal stages of digestion of host hemoglobin and thereby generate a pool of free amino acids that are essential for parasite growth and development. Here, we show that an orally bioavailable aminopeptidase inhibitor, CHR-2863, is ef ...[more]