Ontology highlight
ABSTRACT:
SUBMITTER: Zhu X
PROVIDER: S-EPMC3370894 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Zhu Xiaofeng X Yan Xuan X Carter Lester G LG Liu Huanting H Graham Shirley S Coote Peter J PJ Naismith James J
Acta crystallographica. Section F, Structural biology and crystallization communications 20120522 Pt 6
The removal of chemically damaged DNA bases such as 3-methyladenine (3-MeA) is an essential process in all living organisms and is catalyzed by the enzyme 3-MeA DNA glycosylase I. A key question is how the enzyme selectively recognizes the alkylated 3-MeA over the much more abundant adenine. The crystal structures of native and Y16F-mutant 3-MeA DNA glycosylase I from Staphylococcus aureus in complex with 3-MeA are reported to 1.8 and 2.2 Å resolution, respectively. Isothermal titration calorime ...[more]