Ontology highlight
ABSTRACT:
SUBMITTER: Tesmer JJ
PROVIDER: S-EPMC3370896 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Tesmer John J G JJ Nance Mark R MR Singh Puja P Lee Harie H
Acta crystallographica. Section F, Structural biology and crystallization communications 20120522 Pt 6
G protein-coupled receptor kinase 1 (GRK1 or rhodopsin kinase) phosphorylates activated rhodopsin and initiates a cascade of events that results in the termination of phototransduction by the receptor. Although GRK1 seems to be a monomer in solution, seven prior crystal structures of GRK1 revealed a similar domain-swapped dimer interface involving the C-terminus of the enzyme. The influence of this interface on the overall conformation of GRK1 is not known. To address this question, the crystall ...[more]