Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Gamba A
PROVIDER: S-EPMC3371108 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Fernández-Gamba Agata A Leal María Celeste MC Maarouf Chera L CL Richter-Landsberg Christiane C Wu Terence T Morelli Laura L Roher Alex E AE Castaño Eduardo M EM
Journal of neurochemistry 20120427 6
The extension of processes of oligodendrocyte (OLG) and their precursor cells are crucial for migration, axonal contact and myelination. Here we show that a non-lethal oxidative stress induced by 3-nitropropionic acid (3-NP) elicited a rapid shortening of processes (~24%) in primary OLGs and in oligodendroglial cell line (OLN-93) cells (~36%) as compared with vehicle-exposed cells. This was reversible and prevented by antioxidants. Proteomics of OLG lysates with and without 3-NP treatment yielde ...[more]