Ontology highlight
ABSTRACT:
SUBMITTER: Lee JW
PROVIDER: S-EPMC3371239 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Lee Joo-Won JW Choe Sung Sik SS Jang Hagoon H Kim Jiyeong J Jeong Hyun Woo HW Jo Hyunsun H Jeong Kyeong-Hoon KH Tadi Surendar S Park Myoung Gyu MG Kwak Tae Hwan TH Man Kim Jin J Hyun Dong-Hoon DH Kim Jae Bum JB
Journal of lipid research 20120409 7
In this study, we demonstrate that activation of AMP-activated protein kinase (AMPK) with glabridin alleviates adiposity and hyperlipidemia in obesity. In several obese rodent models, glabridin decreased body weight and adiposity with a concomitant reduction in fat cell size. Further, glabridin ameliorated fatty liver and plasma levels of triglyceride and cholesterol. In accordance with these findings, glabridin suppressed the expression of lipogenic genes such as sterol regulatory element bindi ...[more]