Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh A
PROVIDER: S-EPMC3371359 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Ghosh Arpita A Hartge Patricia P Purdue Mark P MP Chanock Stephen J SJ Amundadottir Laufey L Wang Zhaoming Z Wentzensen Nicolas N Chatterjee Nilanjan N Wacholder Sholom S
Epidemiology (Cambridge, Mass.) 20120701 4
We show how to use reports of cancer in family members to discover additional genetic associations or confirm previous findings in genome-wide association (GWA) studies conducted in case-control, cohort, or cross-sectional studies. Our novel family history-based approach allows economical association studies for multiple cancers, without genotyping of relatives (as required in family studies), follow-up of participants (as required in cohort studies), or oversampling of specific cancer cases (as ...[more]