Ontology highlight
ABSTRACT:
SUBMITTER: Megraw TL
PROVIDER: S-EPMC3371655 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Trends in cell biology 20110531 8
Autosomal recessive primary microcephaly (MCPH) is characterized by small brain size as a result of deficient neuron production in the developing cerebral cortex. Although MCPH is a rare disease, the questions surrounding its etiology strike at the core of stem cell biology. The seven genes implicated in MCPH all encode centrosomal proteins and disruption of the MCPH gene Cdk5rap2 in mice revealed its role in neural progenitor proliferation and in maintaining normal centriole replication control ...[more]