Ontology highlight
ABSTRACT:
SUBMITTER: Lockery SR
PROVIDER: S-EPMC3372093 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Lockery Shawn R SR Hulme S Elizabeth SE Roberts William M WM Robinson Kristin J KJ Laromaine Anna A Lindsay Theodore H TH Whitesides George M GM Weeks Janis C JC
Lab on a chip 20120515 12
This paper describes the fabrication and use of a microfluidic device for performing whole-animal chemical screens using non-invasive electrophysiological readouts of neuromuscular function in the nematode worm, C. elegans. The device consists of an array of microchannels to which electrodes are attached to form recording modules capable of detecting the electrical activity of the pharynx, a heart-like neuromuscular organ involved in feeding. The array is coupled to a tree-like arrangement of di ...[more]