Analysis of transmitted resistance to raltegravir and selective pressure among HIV-1-infected patients on a failing HAART in Sao Paulo, Brazil.
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ABSTRACT:
SUBMITTER: Mantovani NP
PROVIDER: S-EPMC3372140 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
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Analysis of transmitted resistance to raltegravir and selective pressure among HIV-1-infected patients on a failing HAART in Sao Paulo, Brazil.
Mantovani N P NP Azevedo R G RG Rabelato J T JT Sanabani S S Diaz R S RS Komninakis S V SV
Journal of clinical microbiology 20120307 6
We studied the presence of primary resistance to raltegravir (RAL), natural polymorphisms, and selection pressure on HIV-1 integrase. We found a high frequency of integrase polymorphisms related to the resistance to RAL and sequence stability. Further studies are needed to determine the importance of these polymorphisms to RAL resistance. ...[more]
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