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Complete genome sequence of an overattenuated highly pathogenic porcine reproductive and respiratory syndrome virus.

ABSTRACT: JXA1-P170 is an overattenuated highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) that has been passaged in vitro 170 times. Vaccination with JXA1-P170 cannot protect pigs against JXA1 challenge. Compared with the parental virus JXA1, JXA1-P170 contains 1 nucleotide (nt) deletion and 113 nt mutations leading to 59 amino acid substitutions. Here we announce the first complete genome sequence of the overattenuated HP-PRRSV.

SUBMITTER: Wu J 

PROVIDER: S-EPMC3372184 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Complete genome sequence of an overattenuated highly pathogenic porcine reproductive and respiratory syndrome virus.

Wu Jiajun J   Chen Nanhua N   Han Wei W   Cao Zhen Z   Deng Xiaoyu X   Wang Lilin L   Yu Xiuling X   Zhou Zhi Z   Li Xiangdong X   Shi Jishu J   Tian Kegong K  

Journal of virology 20120601 11

JXA1-P170 is an overattenuated highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) that has been passaged in vitro 170 times. Vaccination with JXA1-P170 cannot protect pigs against JXA1 challenge. Compared with the parental virus JXA1, JXA1-P170 contains 1 nucleotide (nt) deletion and 113 nt mutations leading to 59 amino acid substitutions. Here we announce the first complete genome sequence of the overattenuated HP-PRRSV. ...[more]

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