Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC3372198 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Wang Hongjie H Beyer Ines I Persson Jonas J Song Hui H Li ZongYi Z Richter Maximilian M Cao Hua H van Rensburg Ruan R Yao Xiaoying X Hudkins Kelly K Yumul Roma R Zhang Xiao-Bing XB Yu Mujun M Fender Pascal P Hemminki Akseli A Lieber André A
Journal of virology 20120328 11
We have recently reported that a group of human adenoviruses (HAdVs) uses desmoglein 2 (DSG2) as a receptor for infection. Among these are the widely distributed serotypes HAdV-B3 and HAdV-B7, as well as a newly emerged strain derived from HAdV-B14. These serotypes do not infect rodent cells and could not up until now be studied in small-animal models. We therefore generated transgenic mice containing the human DSG2 locus. These mice expressed human DSG2 (hDSG2) at a level and in a pattern simil ...[more]