Ontology highlight
ABSTRACT:
SUBMITTER: Roestenberg M
PROVIDER: S-EPMC3372522 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Roestenberg Meta M O'Hara Geraldine A GA Duncan Christopher J A CJ Epstein Judith E JE Edwards Nick J NJ Scholzen Anja A van der Ven André J A M AJ Hermsen Cornelus C CC Hill Adrian V S AV Sauerwein Robert W RW
PloS one 20120611 6
<h4>Background</h4>Exposing healthy human volunteers to Plasmodium falciparum-infected mosquitoes is an accepted tool to evaluate preliminary efficacy of malaria vaccines. To accommodate the demand of the malaria vaccine pipeline, controlled infections are carried out in an increasing number of centers worldwide. We assessed their safety and reproducibility.<h4>Methods</h4>We reviewed safety and parasitological data from 128 malaria-naïve subjects participating in controlled malaria infection tr ...[more]