Ontology highlight
ABSTRACT:
SUBMITTER: Roy A
PROVIDER: S-EPMC3372652 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20120503 6
Proteins perform functions through interacting with other molecules. However, structural details for most of the protein-ligand interactions are unknown. We present a comparative approach (COFACTOR) to recognize functional sites of protein-ligand interactions using low-resolution protein structural models, based on a global-to-local sequence and structural comparison algorithm. COFACTOR was tested on 501 proteins, which harbor 582 natural and drug-like ligand molecules. Starting from I-TASSER st ...[more]