Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.
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ABSTRACT:
SUBMITTER: Groth C
PROVIDER: S-EPMC3372654 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
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Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.
Groth Casper C Fortini Mark E ME
Seminars in cell & developmental biology 20120130 4
Dysregulated Notch signaling has been implicated in numerous human diseases, including a broad spectrum of cancers. Mutations in Notch1 are prevalent in T-cell acute lymphoblastic leukemia, and abnormal expression of different human Notch receptors contributes to B-cell tumors as well as cancers of the breast, lung, pancreas, skin, prostate, colon, brain and other tissues. Several γ-secretase inhibitors, small chemical compounds that were initially developed to inhibit the activity of the γ-secr ...[more]
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