Lifting the lid on GPCRs: the role of extracellular loops.
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ABSTRACT:
SUBMITTER: Wheatley M
PROVIDER: S-EPMC3372823 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
Lifting the lid on GPCRs: the role of extracellular loops.
Wheatley M M Wootten D D Conner M T MT Simms J J Kendrick R R Logan R T RT Poyner D R DR Barwell J J
British journal of pharmacology 20120301 6
GPCRs exhibit a common architecture of seven transmembrane helices (TMs) linked by intracellular loops and extracellular loops (ECLs). Given their peripheral location to the site of G-protein interaction, it might be assumed that ECL segments merely link the important TMs within the helical bundle of the receptor. However, compelling evidence has emerged in recent years revealing a critical role for ECLs in many fundamental aspects of GPCR function, which supported by recent GPCR crystal structu ...[more]
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