Ontology highlight
ABSTRACT:
SUBMITTER: Qiao B
PROVIDER: S-EPMC3372862 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Qiao Bo B Sugianto Priscilla P Fung Eileen E Del-Castillo-Rueda Alejandro A Del-Castillo-Rueda Alejandro A Moran-Jimenez Maria-Josefa MJ Ganz Tomas T Nemeth Elizabeta E
Cell metabolism 20120601 6
Ferroportin exports iron into plasma from absorptive enterocytes, erythrophagocytosing macrophages, and hepatic stores. The hormone hepcidin controls cellular iron export and plasma iron concentrations by binding to ferroportin and causing its internalization and degradation. We explored the mechanism of hepcidin-induced endocytosis of ferroportin, the key molecular event in systemic iron homeostasis. Hepcidin binding caused rapid ubiquitination of ferroportin in cell lines overexpressing ferrop ...[more]