Ontology highlight
ABSTRACT:
SUBMITTER: Wodarz A
PROVIDER: S-EPMC3372910 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Wodarz Andreas A Stewart Daniel B DB Nelson W James WJ Nusse Roel R
Journal of cell science 20060523 Pt 12
Armadillo, the Drosophila homolog of beta-catenin, plays a crucial role in both the Wingless signal transduction pathway and cadherin-mediated cell-cell adhesion, raising the possibility that Wg signaling affects cell adhesion. Here, we use a tissue culture system that allows conditional activation of the Wingless signaling pathway and modulation of E-cadherin expression levels. We show that activation of the Wingless signaling pathway leads to the accumulation of hypophosphorylated Armadillo in ...[more]