Ontology highlight
ABSTRACT:
SUBMITTER: Morgan AR
PROVIDER: S-EPMC3373076 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Morgan Angharad R AR Lam Wen-Jiun WJ Han Dug-Yeo DY Fraser Alan G AG Ferguson Lynnette R LR
ISRN gastroenterology 20120604
DNase1 has been implicated in a number of immune disorders and is an excellent candidate gene for Crohn's disease (CD). We investigated whether DNase1 SNPs rs1053874 and rs8176938 were associated with CD in a well-characterized New Zealand dataset consisting of 447 cases and 716 controls. Furthermore, we measured serum DNase1 activity levels in a number of CD patients and controls. We did not find any evidence of association for either DNase1 genetic variation or DNase1 activity levels with CD. ...[more]