Ontology highlight
ABSTRACT:
SUBMITTER: Bae Y
PROVIDER: S-EPMC3373245 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Bae Yangjin Y Yang Tao T Zeng Huan-Chang HC Campeau Philippe M PM Chen Yuqing Y Bertin Terry T Dawson Brian C BC Munivez Elda E Tao Jianning J Lee Brendan H BH
Human molecular genetics 20120412 13
During bone homeostasis, osteoblast and osteoclast differentiation is coupled and regulated by multiple signaling pathways and their downstream transcription factors. Here, we show that microRNA 34 (miR-34) is significantly induced by BMP2 during osteoblast differentiation. In vivo, osteoblast-specific gain of miR-34c in mice leads to an age-dependent osteoporosis due to the defective mineralization and proliferation of osteoblasts and increased osteoclastogenesis. In osteoblasts, miR-34c target ...[more]