Ontology highlight
ABSTRACT:
SUBMITTER: Zamorano S
PROVIDER: S-EPMC3373601 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Zamorano Sebastián S Rojas-Rivera Diego D Lisbona Fernanda F Parra Valentina V Court Felipe A FA Court Felipe A FA Villegas Rosario R Cheng Emily H EH Korsmeyer Stanley J SJ Lavandero Sergio S Hetz Claudio C
PloS one 20120612 6
Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic reticulum (ER) stress leads to apoptosis through the upregulation of a subset of pro-apoptotic BH3-only proteins, activating BAX and BAK at the mitochondria. Here we provide evidence indicating that the full resistance of BAX and BAK double deficient (DKO) cells to ER stress is reve ...[more]