Ontology highlight
ABSTRACT:
SUBMITTER: Sharon E
PROVIDER: S-EPMC3374032 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Sharon Eilon E Kalma Yael Y Sharp Ayala A Raveh-Sadka Tali T Levo Michal M Zeevi Danny D Keren Leeat L Yakhini Zohar Z Weinberger Adina A Segal Eran E
Nature biotechnology 20120520 6
Despite extensive research, our understanding of the rules according to which cis-regulatory sequences are converted into gene expression is limited. We devised a method for obtaining parallel, highly accurate gene expression measurements from thousands of designed promoters and applied it to measure the effect of systematic changes in the location, number, orientation, affinity and organization of transcription-factor binding sites and nucleosome-disfavoring sequences. Our analyses reveal a cle ...[more]