Ontology highlight
ABSTRACT:
SUBMITTER: Sivamani P
PROVIDER: S-EPMC3374355 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Sivamani Periyasamy P Singaravelu Ganesan G Thiagarajan Venkatesan V Jayalakshmi Tamilarasu T Ramesh Kumar Gopal G
Bioinformation 20120531 10
Elastase is a protease or proteolytic enzyme, responsible for the breakdown of protein. There are eight human genes encoding for elastase, of which Elastase-1 (CELA-1) and Elastase-2 (ELANE) has significant implications on human diseases. Elastase-1 is primarily expressed in skin keratinocytes and is regarded as the major cause for the blistering in bullous pemphigoid, which affects the skin. On the other hand, Elastase-2 (ELANE), is expressed in the azurophil granules of neutrophils, is respons ...[more]