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Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing.

ABSTRACT: Human leukocyte antigen B (HLA-B) is responsible for presenting peptides to immune cells and plays a critical role in normal immune recognition of pathogens. A variant allele, HLA-B*57:01, is associated with increased risk of a hypersensitivity reaction to the anti-HIV drug abacavir. In the absence of genetic prescreening, hypersensitivity affects ~6% of patients and can be life-threatening with repeated dosing. We provide recommendations (updated periodically at http://www.pharmkgb.org) for the use of abacavir based on HLA-B genotype.

SUBMITTER: Martin MA

PROVIDER: S-EPMC3374459 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing.

Martin M A MA Klein T E TE Dong B J BJ Pirmohamed M M Haas D W DW Kroetz D L DL

Clinical pharmacology and therapeutics 20120229 4

Human leukocyte antigen B (HLA-B) is responsible for presenting peptides to immune cells and plays a critical role in normal immune recognition of pathogens. A variant allele, HLA-B*57:01, is associated with increased risk of a hypersensitivity reaction to the anti-HIV drug abacavir. In the absence of genetic prescreening, hypersensitivity affects ~6% of patients and can be life-threatening with repeated dosing. We provide recommendations (updated periodically at http://www.pharmkgb.org) for the ...[more]

PMID: 22378157

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