Ontology highlight
ABSTRACT:
SUBMITTER: Lee JH
PROVIDER: S-EPMC3374483 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Lee Jung Hoon JH Giannikopoulos Petros P Duncan Stephen A SA Wang Jian J Johansen Christopher T CT Brown Jonathan D JD Plutzky Jorge J Hegele Robert A RA Glimcher Laurie H LH Lee Ann-Hwee AH
Nature medicine 20110612 7
Here we report that the transcription factor cyclic AMP-responsive element-binding protein H (CREB-H, encoded by CREB3L3) is required for the maintenance of normal plasma triglyceride concentrations. CREB-H-deficient mice showed hypertriglyceridemia secondary to inefficient triglyceride clearance catalyzed by lipoprotein lipase (Lpl), partly due to defective expression of the Lpl coactivators Apoc2, Apoa4 and Apoa5 (encoding apolipoproteins C2, A4 and A5, respectively) and concurrent augmentatio ...[more]