A case study for large-scale human microbiome analysis using JCVI's metagenomics reports (METAREP).

ABSTRACT: As metagenomic studies continue to increase in their number, sequence volume and complexity, the scalability of biological analysis frameworks has become a rate-limiting factor to meaningful data interpretation. To address this issue, we have developed JCVI Metagenomics Reports (METAREP) as an open source tool to query, browse, and compare extremely large volumes of metagenomic annotations. Here we present improvements to this software including the implementation of a dynamic weighting of taxonomic and functional annotation, support for distributed searches, advanced clustering routines, and integration of additional annotation input formats. The utility of these improvements to data interpretation are demonstrated through the application of multiple comparative analysis strategies to sho

SUBMITTER: Goll J 

PROVIDER: S-EPMC3374610 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature