Browse
Submit Data
Databases
API
Help

Dataset Information

21 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Fabrication of a hybrid microfluidic system incorporating both lithographically patterned microchannels and a 3D fiber-formed microfluidic network.

ABSTRACT: A device containing a 3D microchannel network (fabricated using sacrificial melt-spun microfibers) sandwiched between lithographically patterned microfluidic channels offers improved delivery of soluble compounds to a large volume compared to a simple stack of two microfluidic channel layers. With this improved delivery ability comes an increased fluidic resistance due to the tortuous network of small-diameter channels.

SUBMITTER: Bellan LM

PROVIDER: S-EPMC3374650 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Fabrication of a hybrid microfluidic system incorporating both lithographically patterned microchannels and a 3D fiber-formed microfluidic network.

Bellan Leon M LM Kniazeva Tatiana T Kim Ernest S ES Epshteyn Alla A AA Cropek Donald M DM Langer Robert R Borenstein Jeffrey T JT

Advanced healthcare materials 20120301 2

A device containing a 3D microchannel network (fabricated using sacrificial melt-spun microfibers) sandwiched between lithographically patterned microfluidic channels offers improved delivery of soluble compounds to a large volume compared to a simple stack of two microfluidic channel layers. With this improved delivery ability comes an increased fluidic resistance due to the tortuous network of small-diameter channels. ...[more]

PMID: 22708076

Similar Datasets

Self-assembly of lithographically patterned nanoparticles.

Project description:The construction of three-dimensional (3D) objects, with any desired surface patterns, is both critical to and easily achieved in macroscale science and engineering. However, on the nanoscale, 3D fabrication is limited to particles with only very limited surface patterning. Here, we demonstrate a self-assembly strategy that harnesses the strengths of well-established 2D nanoscale patterning techniques and additionally enables the construction of stable 3D polyhedral nanoparticles. As a proof of the concept, we self-assembled cubic particles with sizes as small as 100 nm and with specific and lithographically defined surface patterns.

| S-EPMC2791182 | biostudies-literature

Self-loading lithographically structured microcontainers: 3D patterned, mobile microwells.

Project description:We demonstrate mass-producible, mobile, self-loading microcontainers that can be used to encapsulate both non-living and living objects, thus forming three-dimensionally patterned, mobile microwells.

| S-EPMC2562231 | biostudies-literature

Directional Water Wicking on a Metal Surface Patterned by Microchannels.

Project description:This work focuses on the simulation and experimental study of directional wicking of water on a surface structured by open microchannels. Stainless steel was chosen as the material for the structure motivated by industrial applications as fuel cells. Inspired by nature and literature, we designed a fin type structure. Using Selective Laser Melting (SLM) the fin type structure was manufactured additively with a resolution down to about 30 μm. The geometry was manufactured with three different scalings and both the experiments and the simulation show that the efficiency of the water transport depends on dimensionless numbers such as Reynolds and Capillary numbers. Full 3D numerical simulations of the multiphase Navier-Stokes equations using Volume of Fluid (VOF) and Lattice-Boltzmann (LBM) methods reproduce qualitatively the experimental results and provide new insight into the details of dynamics at small space and time scales. The influence of the static contact angle on the directional wicking was also studied. The simulation enabled estimation of the contact angle threshold beyond which transport vanishes in addition to the optimal contact angle for transport.

| S-EPMC7864331 | biostudies-literature

Lithographically Patterned Nanoscale Electrodeposition of Plasmonic, Bimetallic, Semiconductor, Magnetic, and Polymer Nanoring Arrays.

Project description:Large area arrays of magnetic, semiconducting, and insulating nanorings were created by coupling colloidal lithography with nanoscale electrodeposition. This versatile nanoscale fabrication process allows for the independent tuning of the spacing, diameter, and width of the nanorings with typical values of 1.0 μm, 750 nm, and 100 nm, respectively, and was used to form nanorings from a host of materials: Ni, Co, bimetallic Ni/Au, CdSe, and polydopamine. These nanoring arrays have potential applications in memory storage, optical materials, and biosensing. A modified version of this nanoscale electrodeposition process was also used to create arrays of split gold nanorings. The size of the split nanoring opening was controlled by the angle of photoresist exposure during the fabrication process and could be varied from 50% down to 10% of the ring circumference. The large area (cm(2) scale) gold split nanoring array surfaces exhibited strong polarization-dependent plasmonic absorption bands for wavelengths from 1 to 5 μm. Plasmonic nanoscale split ring arrays are potentially useful as tunable dichroic materials throughout the infrared and near-infrared spectral regions.

| S-EPMC4275153 | biostudies-other

Photothermal fabrication of microscale patterned DNA hydrogels.

Project description:This paper introduces a method for fabricating microscale DNA hydrogels using irradiation with patterned light. Optical fabrication allows for the flexible and tunable formation of DNA hydrogels without changing the environmental conditions. Our scheme is based on local heat generation via the photothermal effect, which is induced by light irradiation on a quenching species. We demonstrate experimentally that, depending on the power and irradiation time, light irradiation enables the creation of local microscale DNA hydrogels, while the shapes of the DNA hydrogels are controlled by the irradiation patterns.

| S-EPMC5830774 | biostudies-literature

Observation of hydrophobic-like behavior in geometrically patterned hydrophilic microchannels.

Project description:We present our observation of meta-hydrophobicity, where geometrically patterned surfaces make hydrophilic microchannels exhibit hydrophobic-like behaviors. We analyze the wetting-induced energy decrease that results from the surface geometries and experimentally demonstrate how those geometries can modulate the dynamics of capillary-driven wetting and evaporation-driven drying of microfluidic systems. Our results also show that the modulated wetting dynamics can be employed to generate regulated patterns of microbubbles.

| S-EPMC2966485 | biostudies-other

Fabrication of Microchannels and Evaluation of Guided Vascularization in Biomimetic Hydrogels.

Project description:BackgroundThe fabrication of microchannels in hydrogel can facilitate the perfusion of nutrients and oxygen, which leads to guidance cues for vasculogenesis. Microchannel patterning in biomimetic hydrogels is a challenging issue for tissue regeneration because of the inherent low formability of hydrogels in a complex configuration. We fabricated microchannels using wire network molding and immobilized the angiogenic factors in the hydrogel and evaluated the vasculogenesis in vitro and in vivo.MethodsMicrochannels were fabricated in a hyaluronic acid-based biomimetic hydrogel by using "wire network molding" technology. Substance P was immobilized in acrylated hyaluronic acid for angiogenic cues using Michael type addition reaction. In vitro and in vivo angiogenic activities of hydrogel with microchannels were evaluated.ResultsIn vitro cell culture experiment shows that cell viability in two experimental biomimetic hydrogels (with microchannels and microchannels?+?SP) was higher than that of a biomimetic hydrogel without microchannels (bulk group). Evaluation on differentiation of human mesenchymal stem cells (hMSCs) in biomimetic hydrogels with fabricated microchannels shows that the differentiation of hMSC into endothelial cells was significantly increased compared with that of the bulk group. In vivo angiogenesis analysis shows that thin blood vessels of approximately 25-30 ?m in diameter were observed in the microchannel group and microchannel?+?SP group, whereas not seen in the bulk group.ConclusionThe strategy of fabricating microchannels in a biomimetic hydrogel and simultaneously providing a chemical cue for angiogenesis is a promising formula for large-scale tissue regeneration.

| S-EPMC6171653 | biostudies-literature

Patterned Microstructure Fabrication: Polyelectrolyte Complexes vs Polyelectrolyte Multilayers.

Project description:Polyelectrolyte complexes (PEC) are formed by mixing the solutions of oppositely charged polyelectrolytes, which were hitherto deemed "impossible" to process, since they are infusible and brittle when dry. Here, we describe the process of fabricating free-standing micro-patterned PEC films containing array of hollow or filled microchambers by one-step casting with small applied pressure and a PDMS mould. These structures are compared with polyelectrolyte multilayers (PEM) thin films having array of hollow microchambers produced from a layer-by-layer self-assembly of the same polyelectrolytes on the same PDMS moulds. PEM microchambers "cap" and "wall" thickness depend on the number of PEM bilayers, while the "cap" and "wall" of the PEC microchambers can be tuned by varying the applied pressure and the type of patterned mould. The proposed PEC production process omits layering approaches currently employed for PEMs, reducing the production time from ~2 days down to 2?hours. The error-free structured PEC area was found to be significantly larger compared to the currently-employed microcontact printing for PEMs. The sensitivity of PEC chambers towards aqueous environments was found to be higher compared to those composed of PEM.

| S-EPMC5103270 | biostudies-literature

Scalable Fabrication of Natural-Fiber Reinforced Composites with Electromagnetic Interference Shielding Properties by Incorporating Powdered Activated Carbon.

Project description:Kenaf fiber-polyester composites incorporated with powdered activated carbon (PAC) were prepared using the vacuum-assisted resin transfer molding (VARTM) process. The product demonstrates the electromagnetic interference (EMI) shielding function. The kenaf fibers were retted in a pressured reactor to remove the lignin and extractives in the fiber. The PAC was loaded into the freshly retted fibers in water. The PAC loading effectiveness was determined using the Brunauer-Emmett-Teller (BET) specific surface area analysis. A higher BET value was obtained with a higher PAC loading. The transmission energies of the composites were measured by exposing the samples to the irradiation of electromagnetic waves with a variable frequency from 8 GHz to 12 GHz. As the PAC content increased from 0% to 10.0%, 20.5% and 28.9%, the EMI shielding effectiveness increased from 41.4% to 76.0%, 87.9% and 93.0%, respectively. Additionally, the EMI absorption increased from 21.2% to 31.7%, 44.7% and 64.0%, respectively. The ratio of EMI absorption/shielding of the composite at 28.9% of PAC loading was increased significantly by 37.1% as compared with the control sample. It was indicated that the incorporation of PAC into the composites was very effective for absorbing electromagnetic waves, which resulted in a decrease in secondary electromagnetic pollution.

| S-EPMC5456568 | biostudies-other

Lithographically defined three-dimensional pore-patterned carbon with nitrogen doping for high-performance ultrathin supercapacitor applications.

Project description:Supercapacitors that exhibit long cycle lives and fast charge/discharge rates are a promising energy-storage technology for next-generation mobile or wearable electronic systems. A great challenge facing the fabrication of ultrathin supercapacitor components, specifically their porous electrodes, is whether such components can be integrated with the fabrication of electronic devices, i.e., semiconductor fabrication processes. Here, we introduce the lithographic fabrication of micrometre-thick, submicrometre-pore-patterned carbon for supercapacitor electrodes. The pore patterns designed by multi-beam interference lithography and direct carbonisation of the photoresist pattern produced pore-patterned carbon films. A facile doping process was subsequently employed to introduce nitrogen atoms into the carbon, which was intended to further enhance the carbon's capacitive properties. Specifically, during these fabrication steps, we developed an approach that uses a supporting shell on the surface of the pore patterns to maintain their structural integrity. The nitrogen-doped, pore-patterned carbon electrodes exhibited an areal specific capacitance of 32.7 mF/cm(2) at 0.5 mA/cm(2) when used as supercapacitor electrodes, which is approximately 20 times greater than that of commercially available MWCNT films measured under the same conditions.

| S-EPMC4066249 | biostudies-other

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data