Ontology highlight
ABSTRACT:
SUBMITTER: Curwin AJ
PROVIDER: S-EPMC3374751 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Curwin Amy J AJ von Blume Julia J Malhotra Vivek V
Molecular biology of the cell 20120502 12
The mechanism of cargo sorting at the trans-Golgi network (TGN) for secretion is poorly understood. We previously reported the involvement of the actin-severing protein cofilin and the Ca(2+) ATPase secretory pathway calcium ATPase 1 (SPCA1) in the sorting of soluble secretory cargo at the TGN in mammalian cells. Now we report that cofilin in yeast is required for export of selective secretory cargo at the late Golgi membranes. In cofilin mutant (cof1-8) cells, the cell wall protein Bgl2 was sec ...[more]