Ontology highlight
ABSTRACT:
SUBMITTER: Page T
PROVIDER: S-EPMC3374931 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Page Tristan T Gitcho Michael A MA Mosaheb Sabrina S Carter Deborah D Chakraverty Sumi S Perry Robert H RH Bigio Eileen H EH Gearing Marla M Ferrer Isidre I Goate Alison M AM Cairns Nigel J NJ Thorpe Julian R JR
Journal of molecular neuroscience : MN 20110521 3
Fused in sarcoma (FUS)-immunoreactive neuronal and glial inclusions define a novel molecular pathology called FUS proteinopathy. FUS has been shown to be a component of inclusions of familial amyotrophic lateral sclerosis with FUS mutation and three frontotemporal lobar degeneration entities, including neuronal intermediate filament inclusion disease (NIFID). The pathogenic role of FUS is unknown. In addition to FUS, many neuronal cytoplasmic inclusions (NCI) of NIFID contain aggregates of α-int ...[more]