Ontology highlight
ABSTRACT:
SUBMITTER: Abramkin SA
PROVIDER: S-EPMC3374999 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20101001 20
Novel derivatives of the clinically established anticancer drug oxaliplatin were synthesized. Cytotoxicity of the compounds was studied in six human cancer cell lines by means of the MTT assay. Additionally, most promising complexes were also investigated in cisplatin- and oxaliplatin-resistant human cancer cell models. The therapeutic efficacy in vivo was studied in the murine L1210 leukemia model. Most remarkably, {(1R,2R,4R)-4-methyl-1,2-cyclohexanediamine}oxalatoplatinum(II), comprising an e ...[more]