Ontology highlight
ABSTRACT:
SUBMITTER: Buss JM
PROVIDER: S-EPMC3375436 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Buss Jennifer M JM McTamney Patrick M PM Rokita Steven E SE
Protein science : a publication of the Protein Society 20120301 3
Reductive deiodination is critical for thyroid function and represents an unusual exception to the more common oxidative and hydrolytic mechanisms of dehalogenation in mammals. Studies on the reductive processes have been limited by a lack of convenient methods for heterologous expression of the appropriate proteins in large scale. The enzyme responsible for iodide salvage in the thyroid, iodotyrosine deodinase, is now readily generated after engineering its gene from Mus musculus. High expressi ...[more]