Ontology highlight
ABSTRACT:
SUBMITTER: Tennstaedt A
PROVIDER: S-EPMC3375517 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Tennstaedt Annette A Pöpsel Simon S Truebestein Linda L Hauske Patrick P Brockmann Anke A Schmidt Nina N Irle Inga I Sacca Barbara B Niemeyer Christof M CM Brandt Roland R Ksiezak-Reding Hanna H Tirniceriu Anca Laura AL Egensperger Rupert R Baldi Alfonso A Dehmelt Leif L Kaiser Markus M Huber Robert R Clausen Tim T Ehrmann Michael M
The Journal of biological chemistry 20120425 25
Protective proteases are key elements of protein quality control pathways that are up-regulated, for example, under various protein folding stresses. These proteases are employed to prevent the accumulation and aggregation of misfolded proteins that can impose severe damage to cells. The high temperature requirement A (HtrA) family of serine proteases has evolved to perform important aspects of ATP-independent protein quality control. So far, however, no HtrA protease is known that degrades prot ...[more]