Ontology highlight
ABSTRACT:
SUBMITTER: Wu CC
PROVIDER: S-EPMC3375567 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Wu Ching-Chung CC Naveen Vankadari V Chien Chin-Hsiang CH Chang Yi-Wei YW Hsiao Chwan-Deng CD
The Journal of biological chemistry 20120427 25
The conserved, ATP-dependent bacterial DnaK chaperones process client substrates with the aid of the co-chaperones DnaJ and GrpE. However, in the absence of structural information, how these proteins communicate with each other cannot be fully delineated. For the study reported here, we solved the crystal structure of a full-length Geobacillus kaustophilus HTA426 GrpE homodimer in complex with a nearly full-length G. kaustophilus HTA426 DnaK that contains the interdomain linker (acting as a pseu ...[more]