Ontology highlight
ABSTRACT:
SUBMITTER: Gao Q
PROVIDER: S-EPMC3375643 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Gao Qinghui Q Ho Christine C Jia Yingmin Y Li Jingyi Jessica JJ Huang Haiyan H
Journal of computational biology : a journal of computational molecular cell biology 20120601 6
Identifying a bicluster, or submatrix of a gene expression dataset wherein the genes express similar behavior over the columns, is useful for discovering novel functional gene interactions. In this article, we introduce a new algorithm for finding biClusters with Linear Patterns (CLiP). Instead of solely maximizing Pearson correlation, we introduce a fitness function that also considers the correlation of complementary genes and conditions. This eliminates the need for a priori determination of ...[more]