Ontology highlight
ABSTRACT:
SUBMITTER: Chen GW
PROVIDER: S-EPMC3375880 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Chen Guang-Wu GW Shih Shin-Ru SR
Emerging infectious diseases 20091201 12
Adaptive mutations that have contributed to the emergence of influenza A pandemic (H1N1) 2009 virus, which can replicate and transmit among humans, remain unknown. We conducted a large-scale scanning of influenza protein sequences and identified amino acid-conserving positions that are specific to host species, called signatures. Of 47 signatures that separate avian viruses from human viruses by their nonglycoproteins, 8 were human-like in the pandemic (H1N1) 2009 virus. Close examination of the ...[more]