Ontology highlight
ABSTRACT:
SUBMITTER: Shergill B
PROVIDER: S-EPMC3376165 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Shergill Bhupinder B Meloty-Kapella Laurence L Musse Abdiwahab A AA Weinmaster Gerry G Botvinick Elliot E
Developmental cell 20120531 6
Notch signaling controls diverse cellular processes critical to development and disease. Cell surface ligands bind Notch on neighboring cells but require endocytosis to activate signaling. The role ligand endocytosis plays in Notch activation has not been established. Here we integrate optical tweezers with cell biological and biochemical methods to test the prevailing model that ligand endocytosis facilitates recycling to enhance ligand interactions with Notch necessary to trigger signaling. Sp ...[more]