Ontology highlight
ABSTRACT:
SUBMITTER: Zhu J
PROVIDER: S-EPMC3376167 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Zhu Jing J Martinez-Yamout Maria M Cardoso Rosa R Yan Jiangli J Love Robert A RA Grodsky Neil N Brooun Alexei A Dyson H Jane HJ
The journal of physical chemistry. B 20120327 23
The Per-Arnt-Sim (PAS) domains of hypoxia-inducible transcription factors (HIF) mediate heterodimer formation between the HIF-α forms that are induced in the event of cellular hypoxia and the constitutive HIF-β variants. Previous efforts toward structural characterization of the HIF-1α PAS domains were limited by protein stability. Using homology modeling based on the published crystal structure of the PAS-B domain of the homologous protein HIF-2α in complex with the partner HIF-β (also known as ...[more]