Ontology highlight
ABSTRACT:
SUBMITTER: Lane TJ
PROVIDER: S-EPMC3376171 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Lane Thomas J TJ Pande Vijay S VS
The journal of physical chemistry. B 20120411 23
A simple model is presented that describes general features of protein folding, in good agreement with experimental results and detailed all-atom simulations. Starting from microscopic physics, and with no free parameters, this model predicts that protein folding occurs remarkably quickly because native-like states are kinetic hubs. A hub-like network arises naturally out of microscopic physical concerns, specifically the kinetic longevity of native contacts during a search of globular conformat ...[more]