Ontology highlight
ABSTRACT:
SUBMITTER: Francis BM
PROVIDER: S-EPMC3376325 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Francis Beverly M BM Yang Jimao J Hajderi Enid E Brown Mary E ME Michalski Bernadeta B McLaurin Joanne J Fahnestock Margaret M Mount Howard T J HT
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120411 8
Noradrenergic cell loss is well documented in Alzheimer's disease (AD). We have measured the tissue levels of catecholamines in an amyloid precursor protein-transgenic 'TgCRND8' mouse model of AD and found reductions in noradrenaline (NA) within hippocampus, temporoparietal and frontal cortices, and cerebellum. An age-related increase in cortical NA levels was observed in non-Tg controls, but not in TgCRND8 mice. In contrast, NA levels declined with aging in the TgCRND8 hippocampus. Dopamine lev ...[more]