Ontology highlight
ABSTRACT:
SUBMITTER: Ulitsky I
PROVIDER: S-EPMC3376356 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Ulitsky Igor I Shkumatava Alena A Jan Calvin H CH Sive Hazel H Bartel David P DP
Cell 20111201 7
Thousands of long intervening noncoding RNAs (lincRNAs) have been identified in mammals. To better understand the evolution and functions of these enigmatic RNAs, we used chromatin marks, poly(A)-site mapping and RNA-Seq data to identify more than 550 distinct lincRNAs in zebrafish. Although these shared many characteristics with mammalian lincRNAs, only 29 had detectable sequence similarity with putative mammalian orthologs, typically restricted to a single short region of high conservation. Ot ...[more]