A general method for detecting protease activity via gelation and its application to artificial clotting.
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ABSTRACT:
SUBMITTER: Bremmer SC
PROVIDER: S-EPMC3376645 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
A general method for detecting protease activity via gelation and its application to artificial clotting.
Bremmer Steven C SC Chen Jing J McNeil Anne J AJ Soellner Matthew B MB
Chemical communications (Cambridge, England) 20120427 44
A modular system for detecting protease activity via enzyme-triggered gel formation is described. Protease-specific recognition sequences are utilized to achieve enzyme specificity. Artificial blood clotting is demonstrated by activating endogenous thrombin to trigger gelation in fibrinogen-deficient blood plasma. ...[more]
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