Ontology highlight
ABSTRACT:
SUBMITTER: Donkor MK
PROVIDER: S-EPMC3376999 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Oncoimmunology 20120301 2
TGFβ1 is a regulatory cytokine with a crucial function in the control of T cell tolerance to tumors. Our recent study revealed that T cell-produced TGFβ1 is essential for inhibiting cytotoxic T cell responses to tumors. However, the exact TGFβ1-producing T cell subset required for tumor immune evasion remains unknown. Here we showed that deletion of TGFβ1 from CD8(+) T cells or Foxp3(+) regulatory T (Treg) cells did not protect mice against transplanted tumors. However, absence of TGFβ1 produced ...[more]