Ontology highlight
ABSTRACT:
SUBMITTER: Cattaneo E
PROVIDER: S-EPMC3377079 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Cattaneo Elisa E Laczko Endre E Buffoli Federico F Zorzi Fausto F Bianco Maria Antonia MA Menigatti Mirco M Bartosova Zdena Z Haider Ritva R Helmchen Birgit B Sabates-Bellver Jacob J Tiwari Amit A Jiricny Josef J Marra Giancarlo G
EMBO molecular medicine 20110503 6
Improved colonoscopy is revealing precancerous lesions that were frequently missed in the past, and ∼30% of those detected today have nonpolypoid morphologies ranging from slightly raised to depressed. To characterize these lesions molecularly, we assessed transcription of 23,768 genes in 42 precancerous lesions (25 slightly elevated nonpolypoid and 17 pedunculated polypoid), each with corresponding samples of normal mucosa. Nonpolypoid versus polypoid morphology explained most gene expression v ...[more]