Ontology highlight
ABSTRACT:
SUBMITTER: Smith KM
PROVIDER: S-EPMC3377336 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Smith Kristen M KM Datti Alessandro A Fujitani Mayumi M Grinshtein Natalie N Zhang Libo L Morozova Olena O Blakely Kim M KM Rotenberg Susan A SA Hansford Loen M LM Miller Freda D FD Yeger Herman H Irwin Meredith S MS Moffat Jason J Marra Marco A MA Baruchel Sylvain S Wrana Jeffrey L JL Kaplan David R DR
EMBO molecular medicine 20100901 9
Neuroblastoma (NB) is the most deadly extra-cranial solid tumour in children necessitating an urgent need for effective and less toxic treatments. One reason for the lack of efficacious treatments may be the inability of existing drugs to target the tumour-initiating or cancer stem cell population responsible for sustaining tumour growth, metastases and relapse. Here, we describe a strategy to identify compounds that selectively target patient-derived cancer stem cell-like tumour-initiating cell ...[more]