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Molecular discrimination of sheep bovine spongiform encephalopathy from scrapie.


ABSTRACT: Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We report that the prion protein PrPSc from sheep BSE is extremely resistant to denaturation. This feature, combined with the N-terminal PrPSc cleavage, allowed differentiation of classical scrapie, including CH1641-like, from natural goat BSE and experimental sheep BSE.

SUBMITTER: Pirisinu L 

PROVIDER: S-EPMC3377410 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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Molecular discrimination of sheep bovine spongiform encephalopathy from scrapie.

Pirisinu Laura L   Migliore Sergio S   Di Bari Michele Angelo MA   Esposito Elena E   Baron Thierry T   D'Agostino Claudia C   De Grossi Luigi L   Vaccari Gabriele G   Agrimi Umberto U   Nonno Romolo R  

Emerging infectious diseases 20110401 4


Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We report that the prion protein PrPSc from sheep BSE is extremely resistant to denaturation. This feature, combined with the N-terminal PrPSc cleavage, allowed differentiation of classical scrapie, including CH1641-like, from natural goat BSE and experimental sheep BSE. ...[more]

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