Ontology highlight
ABSTRACT:
SUBMITTER: Gladwin TE
PROVIDER: S-EPMC3377732 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20120618 6
Recent studies suggest that variation in complex disorders (e.g., schizophrenia) is explained by a large number of genetic variants with small effect size (Odds Ratio ≈ 1.05-1.1). The statistical power to detect these genetic variants in Genome Wide Association (GWA) studies with large numbers of cases and controls (v 15,000) is still low. As it will be difficult to further increase sample size, we decided to explore an alternative method for analyzing GWA data in a study of schizophrenia, drama ...[more]