Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin.
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ABSTRACT:
SUBMITTER: Ding Y
PROVIDER: S-EPMC3377767 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin.
Ding Yao Y Gelfenbeyn Kirill K Freire-de-Lima Leonardo L Handa Kazuko K Hakomori Sen-itiroh SI
FEBS letters 20120526 13
Epithelial-mesenchymal transition (EMT) has been shown to play a key role in embryogenesis and cancer progression. We previously found that fibronectin (FN) carrying O-GalNAc at a specific site is selectively expressed in cancer and fetal cells/tissues, and termed oncofetal FN (onfFN). Here, we show that (i) a newly-established monoclonal antibody against FN lacking the O-GalNAc, termed normalFN (norFN), is useful for isolation of onfFN, (ii) onfFN, but not norFN, can induce EMT in human lung ca ...[more]
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