Ontology highlight
ABSTRACT:
SUBMITTER: Madrigal L
PROVIDER: S-EPMC3377850 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Madrigal Lorena L Posthumously Loredana Castrì LC Melendez-Obando Mauricio M Villegas-Palma Ramon R Barrantes Ramiro R Raventos Henrieta H Pereira Reynaldo R Luiselli Donata D Pettener Davide D Barbujani Guido G
American journal of physical anthropology 20120328 3
Estimates of mutation rates for the noncoding hypervariable Region I (HVR-I) of mitochondrial DNA vary widely, depending on whether they are inferred from phylogenies (assuming that molecular evolution is clock-like) or directly from pedigrees. All pedigree-based studies so far were conducted on populations of European origin. In this article, we analyzed 19 deep-rooting pedigrees in a population of mixed origin in Costa Rica. We calculated two estimates of the HVR-I mutation rate, one consideri ...[more]