Ontology highlight
ABSTRACT:
SUBMITTER: Zhao L
PROVIDER: S-EPMC3377938 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Zhao Ling L Jha Babal K BK Wu Ashley A Elliott Ruth R Ziebuhr John J Gorbalenya Alexander E AE Silverman Robert H RH Weiss Susan R SR
Cell host & microbe 20120601 6
Many viruses induce hepatitis in humans, highlighting the need to understand the underlying mechanisms of virus-induced liver pathology. The murine coronavirus, mouse hepatitis virus (MHV), causes acute hepatitis in its natural host and provides a useful model for understanding virus interaction with liver cells. The MHV accessory protein, ns2, antagonizes the type I interferon response and promotes hepatitis. We show that ns2 has 2',5'-phosphodiesterase activity, which blocks the interferon ind ...[more]